Paloxi

PALOXI® shooting DESCRIPTION ® Paloxi (palonosetron hydrochloride) is an antiemetic and anti maladynt agent. It is a serotonin subtype 3 (5-HT3) receptor antagonist with a solid rachis affinity for this receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1oxo-1Hbenz[de]isoquinoline hydrochloride. The empirical formula is C19H24N2O.HCl, with a molecular freight of 332.87. Palonosetron hydrochloride exists as a single isomer and has the following geomorphologic formula: Palonosetron hydrochloride is a white to off -white crystalline powder. It is freely alcohol- meltable in water, soluble in propylene glycol, and meagerly soluble in ethanol and 2 -propanol. ® Paloxi injection is a sterile, clear, colorless, non-pyrogenic, isotonic, buffered outcome for intravenous ® administration. Each 5-ml vial of Paloxi injection contains 0.25 mg palonosetron bow as hydrochloride, 207.5 mg mannitol, edetate disodi um dihydrate, trisodium citratedihydrate, citric aci d monohydrate, and water for injection for intravenous administration. The pH of the solution is 4.5 to 5.5.

CLINICAL PHARMACOLOGY apparatus of Action Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor and litt le or no affinity for other receptors. Cancer chemotherapy may be associated with a high incidence of sickness and vomiting, particularly when certain agents, such as cisplatin, are used. 5-HT3 receptors are located on the warmness terminals of the vagus in the periphery and centrally in the chemoreceptor act zone of the area postre ma. It is thought that chemotherapeutic agen! ts produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small catgut and that the released s erotonin then activates 5-HT3 receptors located on vagal afferents to creative activity father the vomiting reflex. Pharmacodynamics The effect of palonosetron on blood pressure, tenderheartedness rate, and electrocardiogram parameters including QTc...If you want to get a full essay, entrap it on our website: BestEssayCheap.com

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